Nanoparticles with controlled size and high homogeneityParticle size can be controlled from 40 nm to 200 nm with a polydispersity index (PDI) less than 0.2；
Results with high reproducibilityPrecise flow rate control with error ≤ 2%. Automatic switching between products and pre/post-waste, which reduce batch-to-batch variation.
Versatile functionalityNew temperature control and heating modules, with a controllable temperature range from room temperature to 80°C, meeting diverse application needs such as LNP synthesis, liposome synthesis, and drug loading of exosomes.
Hardware and Software UpgradesMore stable liquid delivery and faster response reduce fluid acceleration time by 50%, minimizing reagent consumption. The updated software supports automatic recording and export of experimental parameters.
Wide Chip CompatibilityCompatible with most mainstream microfluidic mixing chips on the market. Optional upgraded metal-glass chips are available for nanoparticle synthesis in strong organic solvent systems such as chloroform and acetone.
During the preparation of nanoparticles (such as LNPs and liposomes), a critical step is the rapid and uniform mixing of the organic phase and buffer within a microfluidic chip. Leveraging advanced microfluidic technology, the Smart Nanoparticle Generator (NP-S2) enables the production of nanoparticles with highly uniform and controllable particle sizes. Validated for its high reproducibility, low sample consumption, and user-friendly operation, the NP-S2 significantly enhances the efficiency of early-stage formulation screening for customers.
Sample Preparation Volume
Total Flow rate
Flow rate Ratio
Heating Module
Software updatable online
Compatible with strong organic solvents
0.4mL – 40mL
0 –40 mL/min
10:1 – 1:30
Room temp – 80℃
Data can be restored, record and reused
Eg. Actone & Dichloromethane
Nanoparticles with controlled size and high homogeneity
Particle size can be controlled from 40 nm to 200 nm with a polydispersity index (PDI) less than 0.2；
Results with high reproducibility
Precise flow rate control with error ≤ 2%. Automatic switching between products and pre/post-waste, which reduce batch-to-batch variation.
Versatile functionality
New temperature control and heating modules, with a controllable temperature range from room temperature to 80°C, meeting diverse application needs such as LNP synthesis, liposome synthesis, and drug loading of exosomes.
Hardware and Software Upgrades
More stable liquid delivery and faster response reduce fluid acceleration time by 50%, minimizing reagent consumption. The updated software supports automatic recording and export of experimental parameters.
Wide Chip Compatibility
Compatible with most mainstream microfluidic mixing chips on the market. Optional upgraded metal-glass chips are available for nanoparticle synthesis in strong organic solvent systems such as chloroform and acetone.
Easy Operation & High Efficiency
Touchscreen control, setup and start preparing within 30 seconds with each run lasting 10–60 seconds. Optional PC control is available for audit trail tracking and tiered access management.
Intelligent Operation Monitoring
Equipped with a built-in pressure sensor, intelligently detect chip clogging and automatically stop operation in time, minimizing reagent and material waste.
B1 is a standard micromixer featuring the classical staggered herringbone structure, ideal for applications such as LNP and liposome synthesis. B1 is made of pure COC, with breaking pressure more than 50 Bar (5 Mpa). It is reusable after proper cleaning.
MTGL-FL-001 chip
This is an optional micromixer configuration composed of 316L stainless steel and glass. Featuring a replaceable glass mixing unit, it offers flexible and customizable mixing structures to suit various applications. It is compatible with strong organic solvents and can be reused after proper cleaning.
Customized chip adapter
This is an optional chip adapter designed for compatibility with NP-S2. It allows you to integrate popular micromixers, cassettes, or chips for nanoparticle synthesis, enhancing flexibility across different workflows.
Experimental Data
Unloaded LNP size distribution (by intensity) after dilution (average size=50.77nm, PDI=0.045)
LNP-mRNA size distribution (by intensity) after dilution (average size=65.765nm, PDI=0.058)
LNP formulated with SARS-CoV-2NTD-RBD mRNA
LNP detected by Cryo-EM
HEK-293T cells transfected by LNP-mRNA (EGFP) detected by FACS. More than 80% cells have GFP signal.
In vivo imaging of mouse injected with LNP-Luciferase mRNA
Parameter
Experimental technical parameters
NP size range
40 – 200 nm
Flow rate ratio (FRR)
10:1 ~ 1:30
Total Flow Rate
0 – 40 mL/min
Flow rate accuracy
Error ≤ 2%
Sample preparation volume
0.4 – 40 mL
Syringe types
Most syringes with Luer connector available on the market (1-20mL)
Chip material
Standard micromixer: COCOptional micromixer: 316L & glass
